Glutaric anhydride → Succinimide glutarate

반응식

[C:1]([O-:9])(=[O:8])[CH2:2][CH2:3][CH2:4][C:5]([O-:7])=[O:6].C1(=O)OC(=O)CCC1.O[N:19]1[C:23](=[O:24])[CH2:22][CH2:21][C:20]1=[O:25].C1(N=C=NC2CCCCC2)CCCCC1>>[C:1]([OH:9])(=[O:8])[CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:20]1(=[O:25])[NH:19][C:23](=[O:24])[CH2:22][CH2:21]1

참가 물질

반응물 4

HCID 7940Glutaric anhydride

HCID 10868Dicyclohexylcarbodiimide

HCID 80170N-Hydroxysuccinimide

HCID 4418048Glutarate(2-)

생성물 1

HCID 86592295Succinimide glutarate

실험 절차

As depicted in above Scheme 2, 6-arm PEG (1) synthesized in the Scheme 1 is reacted with glutarate reagents, e.g., glutaric anhydride to synthesize 6-arm PEG-glutatic acid (6-arm PEG-GA) (2). The compound (2) was reacted with N-hydroxy succinimide (NHS) and N, N′-dicyclohexylcarbodiimide (DCC) to produce 6-arm PEG-succinimide glutarate (6-arm PEG-SG) (3).