Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Succinic Acid → Succinimide succinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Succinic Acid | HCID 1110 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | N-Hydroxysuccinimide | HCID 80170 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Succinic anhydride | HCID 7922 | — |
| 생성물 | Succinimide succinate | HCID 66685880 | — |
반응 단계
As depicted in above Scheme 4, 6-arm PEG (1) synthesized in the Scheme 1 is reacted with succinic reagents, e.g., succinic anhydride and toluene as solvent to synthesize 6-arm PEG-succinic acid (6-arm PEG-SA) (6). The 6-arm PEG SA (6) is reacted with N-hydroxy succinimide (NHS) and N, N′-dicyclohexylcarbodiimide (DCC) to produce 6-arm PEG-succinimide succinate (6-arm PEG-SS) (7).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06858736B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-1a7ed486abdf44a381336bc9e5bad0ba |
| 출처 메모 | uspto-grants-2005_02 |