Butyric anhydride → 8-Chloropropenyl-7-hydroxy-4-methylcoumarin

반응식

[Cl:1][C:2](C)=[CH:3][C:4]1[CH:13]=[C:12]2C(C(C)=CC(=O)[O:11]2)=CC=1.[C:17]([O:22][C:23](=[O:27])[CH2:24][CH2:25][CH3:26])(=O)[CH2:18][CH2:19][CH3:20]>>[Cl:1][CH2:2][CH:3]=[CH:4][C:13]1[C:12]([OH:11])=[CH:20][CH:19]=[C:18]2[C:17]=1[O:22][C:23](=[O:27])[CH:24]=[C:25]2[CH3:26]

참가 물질

반응물 2

HCID 7798Butyric anhydride

HCID 910104567-(2-Chloro propenyl)-4-methyl coumarin

생성물 1

HCID 879765738-Chloropropenyl-7-hydroxy-4-methylcoumarin

반응 조건

온도: 180 °C

실험 절차

A solution of 7-(2-chloro propenyl)-4-methyl coumarin (120 g, 0.48 mol) in a mixture of p-disopropyl-benzene (1 L) and n-butyric anhydride 160 mL was heated to 180° C. for 24 hours. The organic layer was evaporated under reduced pressure and residue recrystallizated from ethanol to afford 75 g of the desired compound.

후처리

customThe organic layer was evaporated under reduced pressure and residue

출처 및 근거

ORD 기록: ord-ff47f270b5784b95a10573b4c08cefc4
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06858742B2

반응 노트

불러오는 중…