Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Peroxide → (4R,4aS,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Peroxide | HCID 784 | — |
| 반응물 | Peracetic Acid | HCID 6585 | — |
| 반응물 | Oxycodone | HCID 5284603 | — |
| 반응물 | Codeinone | HCID 5459910 | — |
| 반응물 | (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline;2,3,4-trihydroxy-4-oxobutanoate | HCID 131728625 | — |
| 용매 | Formic Acid | HCID 284 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | (4R,4aS,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one | HCID 5359420 | — |
반응 단계
Oxycodone has also been prepared from thebaine bitartrate and codeinone ethyldienol ether by oxidation with hydrogen peroxide in formic acid and isopropanol, followed by catalytic hydrogenation5. Oxycodone has also been prepared by the oxidation with peracetic acid of codeinone dienol silylether in organic solvents to give 14-hydroxycodeinone, followed by catalytic hydrogenation in acetic acid solution15.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07875719B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-4a9bcdf3242041dfa8552b1c331e322b |
| 출처 메모 | uspto-grants-2011_01 |