Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 25489생성일: 2026년 10월 23일
3,5-Dichlorophenyl isothiocyanate → 1-(3,5-Dichloro-phenyl)-3-[5-(1H-indol-2-yl)-2-methoxy-phenyl]-thiourea
https://huagongshe.com/ko/reaction/25489
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3,5-Dichlorophenyl isothiocyanate | HCID 138776 | — |
| 반응물 | 5-(1H-indol-2-yl)-2-methoxy-phenylamine | HCID 9900204 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(3,5-Dichloro-phenyl)-3-[5-(1H-indol-2-yl)-2-methoxy-phenyl]-thiourea | HCID 10138249 | — |
반응 단계
The product from Example 1, Step B, 5-(1H-indol-2-yl)-2-methoxy-phenylamine (0.1765 g, 0.74 mmol) was mixed with 3,5-dichlorophenyl isothiocyanate (0.151 g, 0.74 mmol) in ethyl acetate (20 mL) and was heated briefly at 50° C. and then allowed to stand overnight at room temperature. The reaction mixture was concentrated to dryness, triturated with hexanes, and the insoluble material collected by filtration (0.169 g), mp 199-201° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06858739B2 |
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| 출처 데이터셋 | uspto-grants-2005_02 |
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| ORD ID | ord-08c4b7bcaccd40cbb89fe90c35796575 |
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| 출처 메모 | uspto-grants-2005_02 |
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