3-Amino-5-nitrobenzoic acid → (3-Amino-5-nitrophenyl)methanol

HRID 254942

반응식

HRID 254942 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[C:5](O)=[O:6]>C1COCC1>[NH2:1][C:2]1[CH:3]=[C:4]([CH2:5][OH:6])[CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1

참가 물질

3

반응물 1

HCID 2393423-Amino-5-nitrobenzoic acid

생성물 1

HCID 15540036(3-Amino-5-nitrophenyl)methanol수율 89%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-amino-5-nitrobenzoic acid (1.12 g, 6.16 mmol) in THF (5 mL) was added dropwise a solution of borane tetrahydrofuran complex solution (13.6 mL, 13.6 mmol) at ambient temperature and the mixture was stirred for 90 minutes. The solvent was then evaporated. Aqueous NaOH (15 mL) was added and the resulting mixture was extracted with ether. The ether solution was dried over anhydrous Na2SO4. Evaporation of ether afforded 921 mg of the title compound (89%).

후처리

  1. customThe solvent was then evaporated
  2. additionAqueous NaOH (15 mL) was added
  3. extractionthe resulting mixture was extracted with ether
  4. dry with materialThe ether solution was dried over anhydrous Na2SO4
  5. customEvaporation of ether

출처 및 근거

ORD 기록
ord-e35f272e72554c879e05fbbc6fa22fd1
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875728B2

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