Water → 4-[2-(4-Nitrophenyl)ethyl]morpholine

HRID 254943

반응식

HRID 254943 반응식
Br[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.C([O-])([O-])=O.[K+].[K+].O>CC(C)=O>[N+:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:6]=1)([O-:12])=[O:11]

참가 물질

6

반응물 4

HCID 962WaterHCID 8083MorpholineHCID 11430Potassium CarbonateHCID 792664-Nitrophenethyl bromide

생성물 1

HCID 27974734-[2-(4-Nitrophenyl)ethyl]morpholine

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 1-(2-bromoethyl)-4-nitrobenzene (460 mg, 2.0 mmol) in acetone (15 mL) was added morpholine (610 mg, 7.0 mmol) and 680 mg of K2CO3. The mixture was stirred for 80 hours at ambient temperature, and then poured into water. The aqueous mixture was extracted with ether. The organic layer was washed with brine, dried over MgSO4, and evaporated in vacuo to give 456 mg (1.93 mmol; 97%) of the title compound, which was converted to the appropriate amine by the method disclosed in Preparation 16.

후처리

  1. extractionThe aqueous mixture was extracted with ether
  2. washThe organic layer was washed with brine
  3. dry with materialdried over MgSO4
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-d56e25df96604da88774580088e98d59
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875728B2

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