Triethylamine → HCID 178495781, 화합물

HRID 255057

반응식

HRID 255057 반응식
F[C:2]1[CH:18]=[CH:17][C:5]([CH2:6][C:7]2[S:11][C:10](=[NH:12])[N:9]([CH2:13][CH2:14][O:15][CH3:16])[CH:8]=2)=[CH:4][CH:3]=1.[CH2:19]1[CH:26]2[C:22]3([C:28]([OH:30])=O)[CH2:23][CH:24]([CH2:27][CH:20]1[CH2:21]3)[CH2:25]2.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.[F:48][P-](F)(F)(F)(F)F.C(N(CC)CC)C>CN(C=O)C>[F:48][C:17]1[CH:18]=[CH:2][CH:3]=[CH:4][C:5]=1[CH2:6][C:7]1[S:11]/[C:10](=[N:12]\[C:28]([C:22]23[CH2:23][CH:24]4[CH2:27][CH:20]([CH2:19][CH:26]2[CH2:25]4)[CH2:21]3)=[O:30])/[N:9]([CH2:13][CH2:14][O:15][CH3:16])[CH:8]=1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 2733865Hexahydro-2,5-methanopentalene-3a(1H)-carboxylic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 668590705-(4-fluoro-benzyl)-3-(2-methoxyethyl)-3H-thiazol-2-ylidene-amine

생성물 1

HCID 178495781HCID 178495781, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of the product of Example 44A (342 mg, 1.29 mmol), hexahydro-2,5-methano-pentalene-3a-carboxylic acid (256 mg, 1.54 mmol), HATU (737 mg, 1.24 mmol) and triethylamine (1.08 mL, 7.74 mmol) in 20 mL of DMF was processed according to the method of Example 43B to afford the title compound: 1H NMR (500 MHz, DMSO-d6) δ 1.51-1.61 (m, 4 H) 1.65-1.74 (m, 4 H) 2.07 (d, J=9.2 Hz, 2 H) 2.22-2.26 (m, 2 H) 2.51-2.53 (m, 1 H) 3.24 (s, 3 H) 3.66 (t, J=5.3 Hz, 2 H) 3.98 (s, 2 H) 4.23 (t, J=5.3 Hz, 2 H) 7.16-7.22 (m, 3 H) 7.23 (s, 1 H) 7.29-7.38 (m, 2 H); MS (DCI/NH3) m/z 415 (M+H)+.

출처 및 근거

ORD 기록
ord-66c76cf974b34ce29feee551977e05b6
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875639B2

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