Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → HCID 178495754, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Hexahydro-2,5-methanopentalene-3a(1H)-carboxylic acid | HCID 2733865 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 반응물 | 3-(2-methoxy-ethyl)-4,5,6,7-tetrahydro-3H-benzothiazol-2-ylideneamine hydrobromide | HCID 66859028 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178495754 | HCID 178495754 | — |
반응 단계
A mixture of the product of Example 68A (293 mg, 1.00 mmol), hexahydro-2,5-methano-pentalene-3a-carboxylic acid (199 mg, 1.20 mmol), HATU (570 mg, 1.50 mmol) and triethylamine (836 mL, 6.00 mmol) in 15 mL of DMF was processed according to the method of Example 3B to afford the title compound: 1H NMR (500 MHz, DMSO-d6) δ 1.53-1.62 (m, 4 H) 1.67-1.82 (m, 8 H) 2.07-2.12 (m, 2 H) 2.23-2.27 (m, 2 H) 2.45-2.49 (m, 3 H) 2.54-2.59 (m, 2 H) 3.23 (s, 3 H) 3.63 (t, J=5.3 Hz, 2 H) 4.16 (t, J=5.5 Hz, 2 H); MS (DCI/NH3) m/z 361 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07875639B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-effb1b483e274e5ca4fba9500e2f1d6d |
| 출처 메모 | uspto-grants-2011_01 |