참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Thiazolamine, 5-bromo- | HCID 43600 | — |
| 반응물 | 1-Adamantanecarbonyl chloride | HCID 98915 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(5-bromo-1,3-thiazol-2-yl)adamantane-1-carboxamide | HCID 49760640 | — |
반응 단계
A mixture of 5-bromothiazol-2-amine (3.0 g, 11.5 mmol), adamantane-1-carbonyl chloride (2.74 g, 13.8 mmol), triethylamine (3.2 mL, 23 mmol) and 4-di(methylamino)pyridine (1.1 g) in tetrahydrofuran (100 mL) was heated at 80° C. for 48 hours. The mixture was cooled to ambient temperature, concentrated, diluted with water and extracted with ethyl acetate. The organic extract was dried (Na2SO4), filtered and concentrated. Purification by flash chromatography (silica gel, 25% ethyl acetate/hexanes) afforded the title compound, MS (ESI) m/z 342 (M+H)+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07875639B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_01 |
|---|
| ORD ID | ord-bd8e77ef11af43c8866b7ef80c1fb69c |
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| 출처 메모 | uspto-grants-2011_01 |
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