참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 3-Bromoadamantane-1-carboxylic acid | HCID 30818 | — |
| 반응물 | Potassium Permanganate | HCID 516875 | — |
| 반응물 | Sodium Bisulfite | HCID 23665763 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 83406-09-1 | HCID 12010647 | — |
반응 단계
To a mixture of potassium hydroxide (130 mg, 2.0 mmol) and potassium permanganate (350 mg, 2.2 mmol) in H2O (10 mL) at 50° C. was added 3-bromo-adamantane-1-carboxylic acid (512 mg, 2.0 mmol). The reaction mixture was heated at 98° C. for 18 hours. After cooling to ambient temperature, the mixture was acidified by the addition of 6 N aqueous HCl, then saturated aqueous sodium bisulfite was added. The mixture was extracted with 2-propanol/CH2Cl2 (1:3). The organic extract was concentrated to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07875639B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_01 |
|---|
| ORD ID | ord-72a5d0db12b2499896568952461b4c0c |
|---|
| 출처 메모 | uspto-grants-2011_01 |
|---|
