Triethylamine → 7-Methoxy-3,4-dihydroquinolin-2(1H)-one

HRID 255185노트

반응식

HRID 255185 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[CH2:13](N(CC)CC)C.C[Si](C=[N+]=[N-])(C)C>ClCCl.CO.C(#N)C>[CH3:13][O:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 167693TrimethylsilyldiazomethaneHCID 27857587-Hydroxy-3,4-dihydrocarbostyril

생성물 1

HCID 128994187-Methoxy-3,4-dihydroquinolin-2(1H)-one수율 73%

시약·촉매·용매 1

HCID 22226298HCID 22226298, 화합물용매

실험 절차

A mixture of 7-hydroxy-3,4-dihydroquinolin-2(1H)-one (3.0 g, 17 mmol) and triethyl amine (3.14 mL, 22 mmol) in dichloromethane/methanol/acetonitrile (10:1:10, 168 mL) was treated with (trimethylsilyl)diazomethane (2M solution in hexanes, 10.25 mL, 20.5 mmol). It was stirred over night at room temperature, the solvent was removed under reduced pressure and chromatography on silica gel with hexanes/acetone (1:1) gave 2.2 g (67%) of the product as a colorless solid.

후처리

  1. customthe solvent was removed under reduced pressure and chromatography on silica gel with hexanes/acetone (1:1)

출처 및 근거

ORD 기록
ord-ce70ae46bc034020b05d60f45d7f6552
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875715B2

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