Trifluoroacetic acid → 1-[2-(4-Aminopiperidin-1-yl)ethyl]-7-methoxy-1,4-dihydro-2H-3,1-benzoxazin-2-one
반응식
[CH3:1][O:2][C:3]1[CH:29]=[CH:28][C:6]2[CH2:7][O:8][C:9](=[O:27])[N:10]([CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][CH:16]([NH:19]C(=O)OC(C)(C)C)[CH2:15][CH2:14]3)[C:5]=2[CH:4]=1.FC(F)(F)C(O)=O>ClCCl>[NH2:19][CH:16]1[CH2:15][CH2:14][N:13]([CH2:12][CH2:11][N:10]2[C:5]3[CH:4]=[C:3]([O:2][CH3:1])[CH:29]=[CH:28][C:6]=3[CH2:7][O:8][C:9]2=[O:27])[CH2:18][CH2:17]1참가 물질
4
실험 절차
A solution of tert-butyl {1-[2-(7-methoxy-2-oxo-2H-3,1-benzoxazin-1(4H)-yl)ethyl]piperidin-4-yl}carbamate (Intermediate 107) (319 mg, 0.78 mmol) in dichloromethane (8 mL) was treated at room temperature under vigorous stirring with a trifluoroacetic acid (0.75 mL, 10 mmol). After 2 hours, the reaction mixture was concentrated under reduced pressure to give 324 mg (quantitative) of product as a brown oil.