Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl oxoacetate → 7,8-Difluoroquinoxalin-2(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl oxoacetate | HCID 70211 | — |
| 반응물 | 3,4-Difluorobenzene-1,2-diamine | HCID 2736753 | — |
| 반응물 | 6,7-Difluoro-1,2-dihydroquinoxalin-2-one | HCID 6324339 | — |
| 반응물 | 5,6-difluoroquinoxalin-2(1H)-one | HCID 66775376 | — |
| 생성물 | 7,8-Difluoroquinoxalin-2(1H)-one | HCID 66773436 | 64.3% |
반응 단계
3,4-Difluorobenzene-1,2-diamine (4.6 g, 31.6 mmol) and ethyl oxoacetate (50 wt % in toluene, 13.0 mL, 63.2 mmol) were reacted as described for Intermediate 152 to give 3.7 g of product as an off white solid, mixture with 30% of the regioisomer 5,6-difluoroquinoxalin-2(1H)-one. The mixture was carried on to the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07875715B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-b452eb5bfcf7484e963a655f25c3e386 |
| 출처 메모 | uspto-grants-2011_01 |