1-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile → 1-[2-(4-Aminopiperidin-1-yl)ethyl]-7-bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
반응식
[Br:1][C:2]1[CH:28]=[N:27][C:5]2[O:6][CH2:7][C:8](=[O:26])[N:9]([CH2:10][CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([NH:18]C(=O)OC(C)(C)C)[CH2:14][CH2:13]3)[C:4]=2[CH:3]=1.NC1CCN(CCN2C3C(=CC=C(C#N)C=3)C=CC2=O)CC1>>[NH2:18][CH:15]1[CH2:14][CH2:13][N:12]([CH2:11][CH2:10][N:9]2[C:8](=[O:26])[CH2:7][O:6][C:5]3[N:27]=[CH:28][C:2]([Br:1])=[CH:3][C:4]2=3)[CH2:17][CH2:16]1참가 물질
3
반응물 2
생성물 1
실험 절차
tert-Butyl {1-[2-(7-bromo-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)ethyl]piperidin-4-yl}carbamate (Intermediate 210) (0.85 g) was reacted as described for Intermediate 14. The crude trifluoro acetate of the title compound was used without further purification for the next step (quantitative yield).