Triethylamine → 2-{4-[(tert-Butoxycarbonyl)amino]piperidin-1-yl}-1-methylethyl methanesulfonate

HRID 255388노트

반응식

HRID 255388 반응식
[OH:1][CH:2]([CH3:18])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:6][CH2:5]1.C(N(CC)CC)C.[CH3:26][S:27](Cl)(=[O:29])=[O:28].CS(OCCN1CCC(NC(OC(C)(C)C)=O)CC1)(=O)=O.S([O-])(=O)(=O)C>>[CH3:26][S:27]([O:1][CH:2]([CH3:18])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11]([O:12][C:13]([CH3:14])([CH3:16])[CH3:15])=[O:17])[CH2:6][CH2:5]1)(=[O:29])=[O:28]

참가 물질

6

반응물 5

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 85257MethanesulfonateHCID 568344782-(4-((Tert-butoxycarbonyl)amino)piperidin-1-yl)ethyl methanesulfonateHCID 56973353tert-Butyl (1-(2-hydroxypropyl)piperidin-4-yl)carbamate2회

생성물 1

HCID 866426682-{4-[(tert-Butoxycarbonyl)amino]piperidin-1-yl}-1-methylethyl methanesulfonate

실험 절차

tert-Butyl [1-(2-hydroxypropyl)piperidin-4-yl]carbamate (Intermediate 224, 1.1 g, 4.3 mmol), triethylamine (0.90 mL, 6.5 mmol) and methanesulfonyl chloride (0.37 mL, 4.7 mmol). Were reacted as described for Intermediate 6. The crude mesylate was directly used for the next step.

후처리

  1. customWere reacted

출처 및 근거

ORD 기록
ord-be618c1478714bcfbc9fb22bb65bbd4c
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875715B2

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