Isopropyl iodide → Ethyl 2,6-bis(trifluoromethyl)-4-isopropoxy-3-pyridinecarboxylate

반응식

[F:1][C:2]([F:20])([F:19])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([OH:14])[CH:6]=[C:5]([C:15]([F:18])([F:17])[F:16])[N:4]=1.I[CH:22]([CH3:24])[CH3:23]>>[F:20][C:2]([F:19])([F:1])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([O:14][CH:22]([CH3:24])[CH3:23])[CH:6]=[C:5]([C:15]([F:18])([F:17])[F:16])[N:4]=1

참가 물질

반응물 2

HCID 6362Isopropyl iodide

HCID 178470034HCID 178470034, 화합물

생성물 1

HCID 13882868Ethyl 2,6-bis(trifluoromethyl)-4-isopropoxy-3-pyridinecarboxylate수율 74%

실험 절차

Following the procedure of Example 4, this material was prepared in 74% yield from product of Example 2 and 2-iodopropane as a liquid, nD25 1.4210. Anal. Calc'd. for C13H13F6N1O3 : C, 45.23; H, 3.80.

출처 및 근거

ORD 기록: ord-1a80bc1a164f49d18099bc4bddeb0f2c
출처 데이터셋: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04698093

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