Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Citric Acid → Benzyl 2-methylaziridine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | 2-Methylaziridine | HCID 6377 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Benzyl 2-methylaziridine-1-carboxylate | HCID 21895246 | — |
반응 단계
2-Methyl aziridine is dissolved in CH2Cl2 and triethylamine under argon at 0° C. Benzylchloroformate is added and the contents of the flask are at room temperature overnight. The mixture is poured into 10% citric acid and is extracted with CHCl3. The organic layer is washed with dilute aqueous NaHCO3 and dried over MgSO4. The solution is evaporated to yield N-Cbz-2-methyl aziridine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04698231 |
| 출처 데이터셋 | uspto-grants-1987_10 |
| ORD ID | ord-1a4e7089217245829b297700e2f626b8 |
| 출처 메모 | uspto-grants-1987_10 |