Ethyl 6-hydroxy-7-(prop-2-en-1-yl)-1H-indole-2-carboxylate → HCID 20183534, 화합물

HRID 255508노트

반응식

HRID 255508 반응식
[OH:1][C:2]1[C:10]([CH2:11][CH:12]=[CH2:13])=[C:9]2[C:5]([CH:6]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[NH:8]2)=[CH:4][CH:3]=1>C(O)C.[Pd]>[OH:1][C:2]1[C:10]([CH2:11][CH2:12][CH3:13])=[C:9]2[C:5]([CH:6]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[NH:8]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 13203765Ethyl 6-hydroxy-7-(prop-2-en-1-yl)-1H-indole-2-carboxylate

생성물 1

HCID 20183534HCID 20183534, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The product of step b) was dissolved in dry ethanol (350 ml), treated with 10% Pd/C (0.3 g) and hydrogenated at 35 psi at room temperature until H2 uptake ceased (1.5 hours). The catalyst was filtered off and the filtrate evaporated to dryness.

후처리

  1. custom(1.5 hours)
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate evaporated to dryness

출처 및 근거

ORD 기록
ord-15372c7080454dc689a6f0ecb4b3b457
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04698345

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