Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → HCID 178485978, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Quinoline | HCID 7047 | — |
| 반응물 | Diphosgene | HCID 10426 | — |
| 반응물 | 2,4-Difluorophenol | HCID 123051 | — |
| 반응물 | [4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine | HCID 22567629 | — |
| 반응물 | Sodium bicarbonate ethyl acetate | HCID 86584982 | — |
| 반응물 | HCID 178484847 | HCID 178484847 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178485978 | HCID 178485978 | — |
반응 단계
A solution of 1.5 mmol trichloromethyl-chloroformate (diphosgene) in 20 ml CH2Cl2 was treated at 0° C. with 3 mmol of 2,4-difluoro-phenol and 3 mmol quinoline and then stirred for 3 h at room temperature. The reaction was then cooled (0° C.) and a solution of 1 mmol [4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine (privously prepared from trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride by extraction with aqueous NaHCO3/EtOAc) and 2.5 mmol pyridine in 3 ml CH2Cl2 was added. The reaction was stirred over night at room temperature, evaporated to give crude trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-carbamic acid 2,4-difluoro-phenyl ester which was used directly in the next step, see Example 12.39-12.44.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06858651B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-d3a966ad51af4afeb9e5f375319b6d86 |
| 출처 메모 | uspto-grants-2005_02 |