4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 178527590, 화합물

HRID 25558

반응식

HRID 25558 반응식
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([OH:8])[CH2:4][CH2:3]1.[F:9][C:10]([F:22])([F:21])[C:11]1[CH:16]=[CH:15][C:14]([S:17](Cl)(=[O:19])=[O:18])=[CH:13][CH:12]=1>>[OH:8][C@H:5]1[CH2:6][CH2:7][C@H:2]([NH:1][S:17]([C:14]2[CH:13]=[CH:12][C:11]([C:10]([F:9])([F:21])[F:22])=[CH:16][CH:15]=2)(=[O:19])=[O:18])[CH2:3][CH2:4]1

참가 물질

3

반응물 2

HCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 178511715HCID 178511715, 화합물

생성물 1

HCID 178527590HCID 178527590, 화합물

실험 절차

In analogy to example 11.9, trans-4-amino-cyclohexanol and 4-(trifluoromethyl)-benzenesulfonyl chloride were converted to yield trans-N-(4-Hydroxy-cyclohexyl)-4-trifluoromethyl-benzenesulfonamide as white solid, 176.2° C., MS 322 (M-H).

출처 및 근거

ORD 기록
ord-9d9dadfec2a1402ab73e18658aa5eadf
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858651B2

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