Acetic Acid → Diethyl 4-oxo-4H-quinolizine-1,3-dicarboxylate

HRID 255593

반응식

HRID 255593 반응식
[O-]CC.[Na+].[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C([O:19][CH:20]=[C:21]([C:27](OCC)=O)[C:22]([O:24][CH2:25][CH3:26])=[O:23])C.C(O)(=O)C>C(O)C>[CH2:15]([O:14][C:12]([C:11]1[CH:27]=[C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:20](=[O:19])[N:5]2[C:6]=1[CH:7]=[CH:8][CH:9]=[CH:10]2)=[O:13])[CH3:16]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 6871Diethyl (ethoxymethylene)malonateHCID 75960Ethyl 2-pyridylacetateHCID 2723922Sodium ethoxide

생성물 1

HCID 262620Diethyl 4-oxo-4H-quinolizine-1,3-dicarboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of sodium ethoxide (sodium, 151 mg) in ethanol (20 ml) was added ethyl pyrid-2-ylacetate (1 ml) at room temperature and the mixture was stirred for 1 hour at the same temperature. To the mixture was added diethyl ethoxymethylenemalonate (1.33 ml) at room temperature and the mixture was stirred at room temperature overnight. To the mixture was added acetic acid (0.75 ml) at room temperature and the precipitate was filtered and washed with water to give 1,3-diethoxycarbonyl-4H-quinolizin-4-one (896 mg).

후처리

  1. stirringthe mixture was stirred at room temperature overnight
  2. filtrationthe precipitate was filtered
  3. washwashed with water

출처 및 근거

ORD 기록
ord-1f75550736664cc0bc9eca4bd6b837ec
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04698349

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