Ammonia → 4h-Quinolizin-4-one-3-carboxamide

HRID 255595노트

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HRID 255595 반응식
[CH:1]1[CH:2]=[C:3]([C:12]([OH:14])=O)[C:4](=[O:11])[N:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.C(N1C=CN=C1)([N:17]1C=CN=C1)=O.N>CN(C)C=O>[CH:1]1[CH:2]=[C:3]([C:12]([NH2:17])=[O:14])[C:4](=[O:11])[N:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 682631,1'-CarbonyldiimidazoleHCID 15632080HCID 15632080, 화합물

생성물 1

HCID 119605794h-Quinolizin-4-one-3-carboxamide수율 85.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

To a suspension of 4H-quinolizin-4-one-3-carboxylic acid (2.27 g) in dry N,N-dimethylformamide (22.7 ml) was added 1,1'-carbonyldiimidazole (2.92 g). The resulting suspension was heated to 100° C. and kept for 30 minutes. After cooling to room temperature the resulting solution was treated with dry ammonia and stirred for 20 minutes. The crystals separated was collected by filtration and washed with water to give 4H-quinolizin-4-one-3-carboxamide (1.94 g). mp. 230°-232° C.

후처리

  1. temperatureAfter cooling to room temperature the resulting solution
  2. customThe crystals separated
  3. filtrationwas collected by filtration
  4. washwashed with water

출처 및 근거

ORD 기록
ord-6af7c792e74041599dad84f7e718ff80
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04698349

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