5-Acetyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine → 6-Methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylic acid

HRID 255732

반응식

HRID 255732 반응식
[C:1]([C:4]1[C:5]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[CH:18]=2)=[N:6][C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:8][C:9]=1[CH3:10])(=[O:3])C.Br[O-].[Na+].S(=O)(O)[O-:30].[Na+]>O1CCCC1>[CH3:10][C:9]1[N:8]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:6]=[C:5]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[CH:18]=2)[C:4]=1[C:1]([OH:30])=[O:3]

참가 물질

5

반응물 3

HCID 151474775-Acetyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidineHCID 23665763Sodium BisulfiteHCID 23673712Sodium hypobromite

생성물 1

HCID 151474876-Methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 5-acetyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (1.5 g), tetrahydrofuran (70 ml), sodium hypobromite (70 ml) was stirred for 2 hours at ambient temperature. To the mixture was added an aqueous sodium bisulfite solution. The mixture was washed with diethyl ether (100 ml) and the aqueous solution was acidified to pH 3.0 with 10% hydrochloric acid. The resultant crystals were collected by filtration to give 0.80 g of 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylic acid.

후처리

  1. washThe mixture was washed with diethyl ether (100 ml)
  2. filtrationThe resultant crystals were collected by filtration

출처 및 근거

ORD 기록
ord-19c85a267351462d806f23799a5721f5
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04698340

연결된 노트

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