2-Mercaptobenzoic Acid → S-(1-isoquinolyl-methyl)-2-mercapto-benzoic acid

반응식

Cl[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][N:4]=1.[C:13]([OH:22])(=[O:21])[C:14]1[C:15](=[CH:17][CH:18]=[CH:19][CH:20]=1)[SH:16]>>[C:3]1([CH2:2][S:16][C:15]2[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=2[C:13]([OH:22])=[O:21])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][N:4]=1

참가 물질

반응물 2

HCID 54432-Mercaptobenzoic Acid

HCID 132210311-(Chloromethyl)isoquinoline

생성물 1

HCID 57295078S-(1-isoquinolyl-methyl)-2-mercapto-benzoic acid

실험 절차

Following the procedure described in Example 16 but starting from 1.8 g. of 1-chloromethyl-isoquinoline and 1.54 g. of thiosalicylic acid, 1.1 g. of S-(1-isoquinolyl-methyl)-2-mercapto-benzoic acid are obtained, melting at 170° to 172° C.

출처 및 근거

ORD 기록: ord-b3ae1836f97844b5b46b356e6c6fa6cc
출처 데이터셋: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: USRE032519

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