N-Bromosuccinamide → HCID 13958751, 화합물
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[C:1]1(=[O:16])[N:5]([CH2:6]/[C:7](/[CH3:10])=[CH:8]/[F:9])[C:4](=[O:11])[C:3]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:2]12.[Br:17]NC(=O)CCC(N)=O>C(Cl)(Cl)(Cl)Cl>[F:9]/[CH:8]=[C:7](\[CH2:10][Br:17])/[CH2:6][N:5]1[C:4](=[O:11])[C:3]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:2]2[C:1]1=[O:16]참가 물질
4
실험 절차
A mixture of 1-phthalimido-2-methyl-3-fluoro-2-propene (prepared in Step E) (2.09 g) and N-bromosuccinamide (1.78 g) in carbon tetrachloride (100 ml) was refluxed for 45 min. The cooled mixture is filtered and the filtrate is washed with water, dried and evaporated to leave an almost colorless oil. Chromatography (silica; 20% ether in light petroleum) followed by recrystallization of the major fractions from EtOAc/light petroleum gives:
후처리
- temperaturewas refluxed for 45 min
- filtrationThe cooled mixture is filtered
- washthe filtrate is washed with water
- customdried
- customevaporated
- customto leave an almost colorless oil
- customChromatography (silica; 20% ether in light petroleum) followed by recrystallization of the major fractions from EtOAc/light petroleum
- customgives
출처 및 근거
- ORD 기록
- ord-6bd9c27fd4cc44f7aee7ac57db43ae15
- 출처 데이터셋
- uspto-grants-1987_10
- 특허 번호
- US04699928
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