Trifluoroacetic acid → HCID 178457208, 화합물

HRID 25605

반응식

[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.Cl[C:27]([O:29][C:30]1[CH:35]=[C:34]([F:36])[CH:33]=[C:32]([F:37])[CH:31]=1)=[O:28].[CH2:38]([NH:41][CH3:42])[CH:39]=[CH2:40]>>[F:37][C:32]1[CH:31]=[C:30]([O:29][C:27](=[O:28])[N:2]([C@H:3]2[CH2:4][CH2:5][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:41]([CH2:38][CH:39]=[CH2:40])[CH3:42])[CH2:7][CH2:8]2)[CH3:1])[CH:35]=[C:34]([F:36])[CH:33]=1

참가 물질

반응물 4

HCID 6422Trifluoroacetic acid

HCID 69391N-Methylallylamine

HCID 225676833,5-Difluorophenyl chloroformate

HCID 178484796HCID 178484796, 화합물

생성물 1

HCID 178457208HCID 178457208, 화합물

실험 절차

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 3,5-difluoro-phenyl chloroformate were reacted, followed by treatment with N-allyl-N-methylamine to give trans-{4-[5-(Allyl-methyl-amino)-pentyl]-cyclohexyl}-methyl-carbamic acid 3,5-difluoro-phenyl ester, MS: 409 (MH+).

출처 및 근거

ORD 기록: ord-44b2d973e7714a64813c1ca328b2ebe8
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06858651B2

연결된 노트

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