1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 86741841, 화합물

HRID 256172

반응식

HRID 256172 반응식
[Cl:1][C:2]([C:12]([F:15])([F:14])[F:13])=[CH:3][C@@H:4]1[C@H:6]([C:7]([OH:9])=[O:8])[C:5]1([CH3:11])[CH3:10].Br[CH2:17][C:18]1[CH:23]=[CH:22][N:21]=[C:20]([F:24])[CH:19]=1.N12CCCN=C1CCCCC2>C(#N)C>[Cl:1][C:2]([C:12]([F:13])([F:14])[F:15])=[CH:3][C@@H:4]1[C@H:6]([C:7]([O:9][CH2:17][C:18]2[CH:23]=[CH:22][N:21]=[C:20]([F:24])[CH:19]=2)=[O:8])[C:5]1([CH3:11])[CH3:10]

참가 물질

5

반응물 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 139851684-Bromomethyl-2-fluoropyridineHCID 54318404cis-3-(2-Chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylic acid

생성물 1

HCID 86741841HCID 86741841, 화합물수율 77.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

By the method of Example 21, 0.970 g (0.004 mole) of cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylic acid and 0.75 g (0.004 mole) of 4-bromomethyl-2-fluoropyridine (Example 22) were reacted in the presence of 0.609 g (0.004 mole) of 1,8-diazabicyclo[5.4.0]undec-7-ene in 20 ml of acetonitrile to produce 1.09 g of (2-fluoropyridin-4-yl)methyl cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate, compound 28 in the Tables below. The ir, proton nmr, and 19c nmr spectra were all consistent with the proposed structure.

출처 및 근거

ORD 기록
ord-684fa807a53645169da5617b30b6722f
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04701464

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