Diethyl 5-hydantoylphosphonate → 5-[[2-Nitro-5-(1-pyrrolidinyl)phenyl]methylene]-2,4-imidazolidinedione

HRID 256174노트

반응식

HRID 256174 반응식
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4](P(OCC)(=O)OCC)[NH:3]1.[N+:16]([C:19]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)=[CH:23][C:20]=1[CH:21]=O)([O-:18])=[O:17]>>[N+:16]([C:19]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)=[CH:23][C:20]=1[CH:21]=[C:4]1[NH:3][C:2](=[O:1])[NH:6][C:5]1=[O:7])([O-:18])=[O:17]

참가 물질

3

반응물 2

HCID 3516088Diethyl 5-hydantoylphosphonateHCID 38344452-Nitro-5-(pyrrolidin-1-yl)benzaldehyde

생성물 1

HCID 537987795-[[2-Nitro-5-(1-pyrrolidinyl)phenyl]methylene]-2,4-imidazolidinedione

실험 절차

Prepared from diethyl 2,4-dioxoimidazolidine-5-phosphonate and 2-nitro-5-(1-pyrrolidinyl)benzaldehyde analogous to the procedure of Example (2-1), m.p. 289° C. (dec.), crystallized from DMF-H2O.

후처리

  1. customcrystallized from DMF-H2O

출처 및 근거

ORD 기록
ord-42de328a50404844959ee508fb825a1f
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04701459

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