Diethyl 5-hydantoylphosphonate → N-Cyclohexyl-1-[3-[(2,4-dioxoimidazolidin-5-ylidene)methyl]-4-nitrophenyl]-N-methyl-3-piperidinecarboxamide

HRID 256176노트

반응식

HRID 256176 반응식
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4](P(OCC)(=O)OCC)[NH:3]1.[N+:16]([C:19]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:32][CH2:31][CH2:30][CH:29]([C:33](=[O:42])[N:34]([CH3:41])[CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[CH2:28]2)=[CH:23][C:20]=1[CH:21]=O)([O-:18])=[O:17]>>[CH:35]1([N:34]([CH3:41])[C:33]([CH:29]2[CH2:30][CH2:31][CH2:32][N:27]([C:24]3[CH:25]=[CH:26][C:19]([N+:16]([O-:18])=[O:17])=[C:20]([CH:21]=[C:4]4[NH:3][C:2](=[O:1])[NH:6][C:5]4=[O:7])[CH:23]=3)[CH2:28]2)=[O:42])[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1

참가 물질

3

반응물 2

HCID 3516088Diethyl 5-hydantoylphosphonateHCID 201641522-nitro-5-[3-(N-methyl-N-cyclohexylcarbamoyl)-1-piperidinyl]benzaldehyde

생성물 1

HCID 53710199N-Cyclohexyl-1-[3-[(2,4-dioxoimidazolidin-5-ylidene)methyl]-4-nitrophenyl]-N-methyl-3-piperidinecarboxamide

실험 절차

Prepared from diethyl 2,4-dioxoimidazolidine-5-phosphonate and 2-nitro-5-[3-(N-methyl-N-cyclohexylcarbamoyl)-1-piperidinyl]benzaldehyde analogous to the procedure of Example (2-1), m.p. 153°-162° C., crystallized from MeOH-H2O.

후처리

  1. customcrystallized from MeOH-H2O

출처 및 근거

ORD 기록
ord-57ba92b17d924b00b54ea524b9726496
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04701459

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