Cyanogen Bromide → 2,2-Dimethoxy-1-methylpropylcyanamide

HRID 256243노트

반응식

HRID 256243 반응식
[N:1]#[C:2]Br.[CH3:4][O:5][C:6]([O:11][CH3:12])([CH3:10])[CH:7]([NH2:9])[CH3:8]>O.CO>[CH3:4][O:5][C:6]([O:11][CH3:12])([CH3:10])[CH:7]([NH:9][C:2]#[N:1])[CH3:8]

참가 물질

5

반응물 2

HCID 10476Cyanogen BromideHCID 158518261-Methyl-2,2-dimethoxypropylamine

생성물 1

HCID 201644792,2-Dimethoxy-1-methylpropylcyanamide

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

Cyanogen bromide (424 mg., 4 m moles) was added to a solution of 2,2-dimethoxy-1-methylpropylamine (266 mg., 2 m moles) and KHCO3 (400 mg., 4 m moles) in a mixture of water (2 ml.) and methanol (4 ml.). After 15 minutes the mixture was poured in to water (150 ml.) and the mixture extracted with CH2Cl2. The extract was washed with water and brine, dried (MgSO4) and evaporated to dryness to give 2,2-dimethoxy-1-methylpropylcyanamide as a pale yellow oil (280 mg., 88%) having the following n.m.r. spectrum in CDCl3 : 1.15 (s, 3H); 1.18 (d, 3H); 3.15 (s, 6H); 3.0-3.6 (m, 1H); 4.0 (m, 1H).

후처리

  1. extractionthe mixture extracted with CH2Cl2
  2. washThe extract was washed with water and brine
  3. dry with materialdried (MgSO4)
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-e9d0f8d715f147ec9120a29ad7753af1
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04701556

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