2-Thiophenecarboxylic acid, 3-(isocyanatosulfonyl)-, methyl ester → Methyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate

HRID 256266

반응식

HRID 256266 반응식
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([CH3:10])[N:3]=1.[CH3:11][O:12][C:13]([C:15]1[S:16][CH:17]=[CH:18][C:19]=1[S:20]([N:23]=[C:24]=[O:25])(=[O:22])=[O:21])=[O:14]>C(#N)C>[CH3:9][O:8][C:6]1[CH:5]=[C:4]([CH3:10])[N:3]=[C:2]([NH:1][C:24]([NH:23][S:20]([C:19]2[CH:18]=[CH:17][S:16][C:15]=2[C:13]([O:12][CH3:11])=[O:14])(=[O:21])=[O:22])=[O:25])[N:7]=1

참가 물질

4

반응물 2

HCID 1572962-Thiophenecarboxylic acid, 3-(isocyanatosulfonyl)-, methyl esterHCID 5872364-Methoxy-6-methylpyrimidin-2-amine

생성물 1

HCID 13390184Methyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To 1.4 g of 2-amino-4-methoxy-6-methylpyrimidine in 30 ml of anhydrous acetonitrile was added at ambient temperature, with stirring 3.6 g of 2-methoxycarbonyl-3-thiophenesulfonylisocyanate. The mixture was heated to the boiling point and then allowed to cool to ambient temperature. After stirring for sixteen hours the precipitate present in the mixture was filtered off and washed with anhydrous ethyl ether. The product thus obtained which melted at 165°-173° showed absorption peaks by infrared spectroscopy at 1720 and 1700 cm-1, consistent for the carbonyl groups in the desired product.

후처리

  1. temperatureThe mixture was heated to the boiling point
  2. filtrationwas filtered off
  3. washwashed with anhydrous ethyl ether
  4. customThe product thus obtained which melted at 165°-173°
  5. customabsorption peaks by infrared spectroscopy at 1720 and 1700 cm-1

출처 및 근거

ORD 기록
ord-71fdcd695fb245e8be245884ebf3a9da
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04701535

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