HCID 178474351, 화합물 → HCID 178507948, 화합물
반응식
C([NH:4][C:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][C:6]=1[C:14]([NH:16][C:17]1[NH:21][N:20]=[N:19][N:18]=1)=[O:15])(=O)C>C(O)C>[NH2:4][C:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][C:6]=1[C:14]([NH:16][C:17]1[NH:21][N:20]=[N:19][N:18]=1)=[O:15]참가 물질
3
실험 절차
A mixture of 5.3 g (0.019 mole) of 3-(acetylamino)N-1H-tetrazol-5-yl-2-benzofurancarboxamide in 50 ml of ethanol plus 50 ml of concentrated (12.0 M) hydrochloric acid is stirred at reflux for two hours. The reaction mixture is cooled in ice to precipitate 3-amino-N-1H-tetrazol-5-yl-2-benzofurancarboxamide. The precipitate is filtered, washed with 50% aqueous ethanol, and recrystallized from aqueous 2-methoxyethanol to yield 2.4 g (53% yield) of the analytically pure 3-amino-N-1H-tetrazol-5-yl-2-benzofurancarboxamide, mp 275° C.-dec.
후처리
- concentrationof concentrated (12.0 M) hydrochloric acid
- temperatureat reflux for two hours
- temperature