1-Pyrrolidineacetic acid, 4-hydroxy-2-oxo-, (+-)- → 1-[2-(4-Hydroxy-2-oxo-1-pyrrolidineacetamido)acetyl]-2,2,5-trimethyl-4-imidazolidinone

HRID 256380노트

반응식

HRID 256380 반응식
[OH:1][CH:2]1[CH2:6][N:5]([CH2:7][C:8]([OH:10])=O)[C:4](=[O:11])[CH2:3]1.[NH2:12][CH2:13][C:14]([N:16]1[CH:20]([CH3:21])[C:19](=[O:22])[NH:18][C:17]1([CH3:24])[CH3:23])=[O:15]>>[OH:1][CH:2]1[CH2:6][N:5]([CH2:7][C:8]([NH:12][CH2:13][C:14]([N:16]2[CH:20]([CH3:21])[C:19](=[O:22])[NH:18][C:17]2([CH3:23])[CH3:24])=[O:15])=[O:10])[C:4](=[O:11])[CH2:3]1

참가 물질

3

반응물 2

HCID 111265411-Pyrrolidineacetic acid, 4-hydroxy-2-oxo-, (+-)-HCID 201637481-(2-Aminoacetyl)-2,2,5-trimethyl-4-imidazolidinone

생성물 1

HCID 542246001-[2-(4-Hydroxy-2-oxo-1-pyrrolidineacetamido)acetyl]-2,2,5-trimethyl-4-imidazolidinone

실험 절차

The same procedure of Example 11, starting from 4-hydroxy-2-oxo-1-pyrrolidineacetic acid and 1-(2-aminoacetyl)-2,2,5-trimethyl-4-imidazolidinone, gave the title compound as a diastereoisomeric mixture, m.p. 218°-220° C. Mass spectrum (E.I., 70 eV, 1.5 mA), m/z=269 (M.+ --C3H7N).

출처 및 근거

ORD 기록
ord-2118975caecb4611aaab8278e4068f83
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04703054

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