Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 1-(Benzyloxy)-2-(chloromethyl)benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Salicyl Alcohol | HCID 5146 | — |
| 반응물 | Benzyl Chloride | HCID 7503 | — |
| 반응물 | Benzenemethanol, 2-(phenylmethoxy)- | HCID 18811 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 1-(Benzyloxy)-2-(chloromethyl)benzene | HCID 563507 | 81% |
반응 단계
To a solution of 46.5 (0.217 mole) 2-benzyloxybenzyl alcohol (prepared by reaction of 2-hydroxybenzyl alcohol with benzyl chloride in ethanol containing an equimolar amount of potassium t-butoxide at 100° C.) in 100 ml chloroform was added 17.2 g (0.217 mole) pyridine followed by dropwise addition of a solution of 25.8 g (0.217 mole) thionyl chloride in 60 ml chloroform. The resulting mixture was heated at reflux for 1.5 hours, cooled, washed with water, brine and dried (MgSO4). Evaporation of solvent gave 45.8 g crude oil which was distilled in vacuo to yield 40.7 g (81%) of product as a colorless oil, b.p. 141° C.(1 Torr).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04703052 |
| 출처 데이터셋 | uspto-grants-1987_10 |
| ORD ID | ord-e57e3edb022740a8926893137e99290e |
| 출처 메모 | uspto-grants-1987_10 |