Pyridine → 4-[[8-[(4-Methylphenyl)sulfonyl]octyl]oxy]-1,1-biphenyl

HRID 256501노트

반응식

HRID 256501 반응식
[C:1]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:6]=[CH:5][C:4]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]O)=[CH:3][CH:2]=1.[S:23](Cl)([C:26]1[CH:32]=[CH:31][C:29]([CH3:30])=[CH:28][CH:27]=1)(=[O:25])=[O:24].N1C=CC=CC=1>O>[CH3:30][C:29]1[CH:31]=[CH:32][C:26]([S:23]([CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][O:7][C:4]2[CH:5]=[CH:6][C:1]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:2][CH:3]=2)(=[O:25])=[O:24])=[CH:27][CH:28]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 139591154-(8-Hydroxyoctyl)oxybiphenyl

생성물 1

HCID 230435324-[[8-[(4-Methylphenyl)sulfonyl]octyl]oxy]-1,1-biphenyl

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 33.26 g of 8-([1,1'-biphenyl]-4-yl-oxy)-1-octanol, 23.37 g of tosyl chloride and 200 ml of pyridine was allowed to stand in a refrigerator overnight. Then water was added, the solid collected, washed with water and dissolved in chloroform. This solution was washed with dilute hydrochloric acid then saturated aqueous sodium bicarbonate, dried and the solvent removed, giving the desired compound as a white solid.

후처리

  1. customto stand in a refrigerator overnight
  2. customthe solid collected
  3. washwashed with water
  4. dissolutiondissolved in chloroform
  5. washThis solution was washed with dilute hydrochloric acid
  6. dry with materialsaturated aqueous sodium bicarbonate, dried
  7. customthe solvent removed

출처 및 근거

ORD 기록
ord-fdef6fc129804af98d0c893e93407767
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04703130

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