참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Menthol | HCID 1254 | — |
| 반응물 | diethyl 2-(1H-pyrrol-1-yl)malonate | HCID 2782128 | — |
| 촉매 | Titanium(IV)ethoxide | HCID 2724286 | — |
| 생성물 | 2-(Pyrrol-1-yl)malonic acid ethyl (-)-menthyl ester | HCID 53871925 | 31.8% |
반응 단계
To a mixture of 2-(pyrrol-1-yl)malonic acid diethyl ester (300.0 g) and (-)-menthol (417.0 g) was added tetraethyl titanate (10.0 g), and the resulting mixture was stirred at 110° C. for 19 hours. After removal of the (-)-menthol under reduced pressure, the residue was chromatographed on silica gel using n-hexane/ethyl acetate (50:1) as the eluent. Fractions containing the title compound were pooled and evaporated under reduced pressure to give the title compound (142.0 g, 31.8%) as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05258382 |
|---|
| 출처 데이터셋 | uspto-grants-1993_11 |
|---|
| ORD ID | ord-f14a8b62c6884870a484f598b5c82ebb |
|---|
| 출처 메모 | uspto-grants-1993_11 |
|---|
