2-Benzyloxycarbonylmethyl-2-(pyrrol-1-yl)malonic acid diethyl ester → 2-Carboxymethyl-2-(pyrrol-1-yl)-malonic acid diethyl ester

HRID 256583

반응식

HRID 256583 반응식
[CH2:1]([O:3][C:4](=[O:27])[C:5]([CH2:16][C:17]([O:19]CC1C=CC=CC=1)=[O:18])([N:11]1[CH:15]=[CH:14][CH:13]=[CH:12]1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2]>O1CCOCC1.[C].[Pd]>[CH2:1]([O:3][C:4](=[O:27])[C:5]([CH2:16][C:17]([OH:19])=[O:18])([N:11]1[CH:12]=[CH:13][CH:14]=[CH:15]1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2]

참가 물질

4

반응물 1

HCID 106193402-Benzyloxycarbonylmethyl-2-(pyrrol-1-yl)malonic acid diethyl ester

생성물 1

HCID 108029052-Carboxymethyl-2-(pyrrol-1-yl)-malonic acid diethyl ester수율 80.2%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 312751,4-Dioxane용매

실험 절차

A mixture of 2-benzyloxycarbonylmethyl-2-(pyrrol-1-yl)malonic acid diethyl ester (80.0 g) in dioxane (150 ml) was hydrogenated over 10% palladium-carbon (500 mg) at 40° C. After the calculated amount of hydrogen was absorbed, the catalyst was filtered off and the filtrate was evaporated under reduced pressure. The residue was recrystallized from ethyl acetate/n-hexane to give the title compound (48.7 g, 80.2%) as colorless crystals, mp 93°-94° C.

후처리

  1. customAfter the calculated amount of hydrogen was absorbed
  2. filtrationthe catalyst was filtered off
  3. customthe filtrate was evaporated under reduced pressure
  4. customThe residue was recrystallized from ethyl acetate/n-hexane

출처 및 근거

ORD 기록
ord-aaf7310e824b4202a08add87a34cb156
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05258382

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