Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → Ethyl 2-(((benzyloxy)carbonyl)amino)-2-cyanoacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 반응물 | Ethyl 2-amino-2-cyanoacetate | HCID 288716 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Ethyl 2-(((benzyloxy)carbonyl)amino)-2-cyanoacetate | HCID 9943163 | 60.2% |
반응 단계
To a stirred mixture of 2-amino-2-cyanoacetic acid ethyl ester (19.7 g) and pyridine (12.2 g) in water (123 ml) was added portionwise benzyloxycarbonyl chloride (27.9 g) under ice cooling. The resulting mixture was stirred under ice cooling for 1 hour. Precipitated crystals were collected, washed thoroughly with water, and recrystallized from ethanol to give the title compound (24.2 g, 60.2%) as colorless crystals, mp 111°-112° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05258382 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-4ea026a1293a48e196c3c781eb05705b |
| 출처 메모 | uspto-grants-1993_11 |