Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → Nilvadipine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Phosphorus pentachloride | HCID 24819 | — |
| 반응물 | 6-Cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid | HCID 15388766 | — |
| 생성물 | Nilvadipine | HCID 4494 | 97.6% |
반응 단계
Methyl (-)-5-carboxy-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate (4.47 g) is reacted with phosphorus pentachloride (3.62 g) and isopropyl alcohol (2.5 g) in the same manner as in Example 7 to provide 5-isopropyl 3-methyl (-)-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (4.9 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05258393 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-e90cb37427224c40bfdf5480d8f2d9c9 |
| 출처 메모 | uspto-grants-1993_11 |