Dichloromethane → 1-Cycloheptyl-1-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)-3-[p-(N,N-dimethylamino)phenyl]urea monohydrochloride

HRID 256628

반응식

HRID 256628 반응식
[CH:1]1([NH:8][C:9]2[C:14]3[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[CH:12]=[CH:11][CH:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:20][N:21]([C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[O:31])=[CH:25][CH:24]=1)[CH3:22].[Cl:32]CCl>>[ClH:32].[CH:1]1([N:8]([CH:9]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:19][C:18]=3[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:30]([NH:29][C:26]2[CH:27]=[CH:28][C:23]([N:21]([CH3:22])[CH3:20])=[CH:24][CH:25]=2)=[O:31])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 27333724-(Dimethylamino)phenyl isocyanateHCID 19936134N-Cycloheptyl-(6,7,8,9-tetrahydro-5H-benzocycloheptenyl)amine

생성물 1

HCID 197856731-Cycloheptyl-1-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)-3-[p-(N,N-dimethylamino)phenyl]urea monohydrochloride

실험 절차

N-Cycloheptyl-(6,7,8,9-tetrahydro-5H-benzocycloheptenyl)amine (0.8 g, 3.1 mmol) and 4-(N,N-dimethyamino)phenylisocyanate (0.50 g, 3.1 mmol) was stirred in dichloromethane (10 ml) at room temperature for 18 hrs. The reaction mixture was then purified by silica gel column chromatography. The resulting urea compound was treated with hydrochloric acid in ether to give 0.72 g of the above hydrochloride compound.

후처리

  1. customThe reaction mixture was then purified by silica gel column chromatography
  2. additionThe resulting urea compound was treated with hydrochloric acid in ether

출처 및 근거

ORD 기록
ord-800be3c29d3c4823bcf858405f1ec5aa
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05258405

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