Pyridine → N-(4-amino-5-pyrimidinyl)-4-fluorobenzamide

HRID 256634노트

반응식

HRID 256634 반응식
[N:1]1[CH:6]=[C:5]([NH2:7])[C:4]([NH2:8])=[N:3][CH:2]=1.N1C=CC=CC=1.CN(C)C=O.[F:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1>O>[NH2:8][C:4]1[C:5]([NH:7][C:25](=[O:26])[C:24]2[CH:28]=[CH:29][C:21]([F:20])=[CH:22][CH:23]=2)=[CH:6][N:1]=[CH:2][N:3]=1

참가 물질

6

반응물 4

HCID 1049PyridineHCID 6228Dimethylformamide2회HCID 678794-Fluorobenzoyl chlorideHCID 837034,5-Diaminopyrimidine

생성물 1

HCID 19785297N-(4-amino-5-pyrimidinyl)-4-fluorobenzamide수율 70%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred mixture of 20.2 parts of 4,5-pyrimidinediamine, 40 parts of pyridine and 144 parts of N,N-dimethylformamide was added dropwise a solution of 24.2 parts of 4-fluorobenzoyl chloride in 36 parts of N,N-dimethylformamide at 10° C. Upon completion, stirring was continued for 30 minutes at room temperature. 600 Parts of water were added. The product was filtered off and dried, yielding 30 parts (70%) of N-(4-amino-5-pyrimidinyl)-4-fluorobenzamide (interm. 11).

후처리

  1. filtrationThe product was filtered off
  2. customdried

출처 및 근거

ORD 기록
ord-296f035cade34f5380d88441c6b5ee95
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05258380

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