Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 2-(1-Adamantyl)-4-bromophenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 4-Bromophenol | HCID 7808 | — |
| 반응물 | 1-Adamantanol | HCID 64152 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(1-Adamantyl)-4-bromophenol | HCID 4670494 | — |
반응 단계
34.6 g (200 mmol) of p-bromophenol and 30.4 g (200 mmol) of 1 -adamantanol are dissolved in 100 ml of dichloromethane. To the resulting solution there are slowly added 10 ml of concentrated sulfuric acid. The mixture is stirred for 8 hours at ambient temperature poured into water, neutralized with sodium bicarbonate, extracted with methylene chloride, dried and evaporated. After recrystallization in isooctane 52.8 g of the expected product are obtained. Yield--86%. Melting point: 140°-141° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE034440 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-69f3d89a8ff740c5ab42f0fc4d0570ac |
| 출처 메모 | uspto-grants-1993_11 |