1,2,4-Oxadiazole, 5-cyclopropyl-3-(isocyanomethyl)- → HCID 19784292, 화합물

반응식

Cl[C:2]1[N:11]2[CH:12]=[N:13][N:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[CH:15]1([C:18]2[O:22][N:21]=[C:20]([CH2:23][N+:24]#[C-:25])[N:19]=2)[CH2:17][CH2:16]1.CC(C)([O-])C.[K+]>CN(C=O)C>[CH:15]1([C:18]2[O:22][N:21]=[C:20]([C:23]3[N:24]=[CH:25][N:3]4[C:4]5[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=5[C:10]5=[N:14][N:13]=[CH:12][N:11]5[C:2]=34)[N:19]=2)[CH2:17][CH2:16]1

참가 물질

실험 절차

To a stirred slurry of 5-chloro-1,2,4-triazolo[4,3-c]quinazoline (3.5 g, 17 mmol) in 40 ml of dry DMF at 10° C. was first added 5-cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazole (purity 80%, 3.4 g, 18 mmol) and then a solution of potassium tert-butoxide (2.55 g, 23 mmol) in 40 ml of DMF, allowing the temperature to rise to room temperature. After 1/2 h the mixture was filtered and the filter cake washed with water and finally with ether and dried, giving the title compound as colorless crystals, m.p. 308°-314° C.