1-(4-Methoxyphenyl)-piperazine, dihydrochloride → 3-{2-[4-(4-Methoxyphenyl)-1-piperazinyl]ethyl}-2-trifluoroacetylimino-6-trifluoromethoxybenzothiazoline hydrochloride

HRID 256826

반응식

HRID 256826 반응식
[ClH:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17]C3C4NC(=NC(=O)C(F)(F)F)SC=4C=C(OC(F)(F)F)C=3)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.CS(OCC[N:46]1[C:50]2[CH:51]=[CH:52][C:53]([O:55][C:56]([F:59])([F:58])[F:57])=[CH:54][C:49]=2[S:48][C:47]1=[N:60][C:61](=[O:66])[C:62]([F:65])([F:64])[F:63])(=O)=O.Cl.Cl.COC1C=CC(N2CCNCC2)=CC=1>C1(C)C=CC=CC=1>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][N:46]3[C:50]4[CH:51]=[CH:52][C:53]([O:55][C:56]([F:59])([F:57])[F:58])=[CH:54][C:49]=4[S:48][C:47]3=[N:60][C:61](=[O:66])[C:62]([F:63])([F:64])[F:65])[CH2:14][CH2:15]2)=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 27237001-(4-Methoxyphenyl)-piperazine, dihydrochlorideHCID 157348642-(2-Trifluoroacetylimino-6-trifluoromethoxy-3-benzothiazolinyl)ethyl methanesulphonateHCID 178491970HCID 178491970, 화합물

생성물 1

HCID 197842683-{2-[4-(4-Methoxyphenyl)-1-piperazinyl]ethyl}-2-trifluoroacetylimino-6-trifluoromethoxybenzothiazoline hydrochloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

3-{2-[4-(4-Methoxyphenyl)-1-piperazinyl]ethyl-2-trifluoroacetylimino-6-trifluoromethoxybenzothiazoline hydrochloride may be prepared in the following manner: a mixture of 2-(2-trifluoroacetylimino-6-trifluoromethoxy-3-benzothiazolinyl)ethyl methanesulphonate (4.52 g), toluene (120 cc) and the base liberated from 4-(p-methoxyphenyl)piperazine dihydrochloride (10.56 g) is heated to reflux for 1 hour, cooled to +4° C. and then drained. The toluene filtrate is evaporated under reduced pressure and then treated with 1.2N aqueous hydrochloric acid solution (45 cc). The hydrochloride separates in amorphous form and then crystallizes on grinding with ethanol (50 cc). After draining, washing with ethanol (15 cc) and drying at 50° C. at 20 mmHg, 3-{2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl}-2-trifluoroacetylimino-6-trifluoromethoxybenzothiazoline hydrochloride (1.7 g) is obtained.

후처리

  1. temperatureis heated
  2. temperatureto reflux for 1 hour
  3. temperaturecooled to +4° C.
  4. customThe toluene filtrate is evaporated under reduced pressure
  5. additiontreated with 1.2N aqueous hydrochloric acid solution (45 cc)
  6. customcrystallizes
  7. customon grinding with ethanol (50 cc)
  8. washwashing with ethanol (15 cc)
  9. customdrying at 50° C. at 20 mmHg

출처 및 근거

ORD 기록
ord-ee377dbe5f194db99304f6eff0dad590
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05260297

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