Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-(3-(3-Methyl-2-butenyloxy)-1,2,5-thiadiazol-4-yl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 3-Methyl-2-buten-1-OL | HCID 11173 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole | HCID 10488164 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(3-(3-Methyl-2-butenyloxy)-1,2,5-thiadiazol-4-yl)pyridine | HCID 19075325 | — |
반응 단계
To a solution of 3-methyl-2-buten-1-ol (780 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 0.3 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05260311 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-7d2e3a111b8245799c79db0dc2d036c9 |
| 출처 메모 | uspto-grants-1993_11 |