HCID 19783098, 화합물 → Ethyl 4-oxotetrahydro-2H-pyran-3-carboxylate

반응식

[CH2:1]([O:3][C:4]([C:6]1(F)[C:11](=[O:12])[CH2:10][CH2:9][O:8][CH2:7]1)=[O:5])[CH3:2].C(OC(C1(F)C(O)CCOC1)=O)C>>[CH2:1]([O:3][C:4]([CH:6]1[C:11](=[O:12])[CH2:10][CH2:9][O:8][CH2:7]1)=[O:5])[CH3:2]

참가 물질

반응물 2

HCID 19783098HCID 19783098, 화합물

HCID 67884933Ethyl 3-fluoro-4-oxooxane-3-carboxylate

생성물 1

HCID 19783095Ethyl 4-oxotetrahydro-2H-pyran-3-carboxylate

실험 절차

First, 3-ethoxycarbonyl-tetrahydro-4H-pyran4-one was synthesized referring the process described in Japan Laid-Open Patent Publication No. 32080/90. Then this ester was fluorinated in the same manner as in Example 4 to prepare 3-ethoxycarbony-3-fluoro-tetrahydro-4H-pyran-4-one which was then reduced in the same manner as in the same example to prepare 3-ethoxycarbonyl-3-fluoro-4-hydroxytetrahydro-4H-pyran.

출처 및 근거

ORD 기록: ord-3bfa8bb644a84be8afedaf3d292605c9
출처 데이터셋: uspto-grants-1993_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05262385

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