HCID 18953543, 화합물 → 4-(1H-imidazol-1-yl)pyridin-3-amine

HRID 257417노트

반응식

HRID 257417 반응식
[N:1]1([C:6]2[CH:11]=[CH:10][N:9]=[CH:8][C:7]=2[N+:12]([O-])=O)[CH:5]=[CH:4][N:3]=[CH:2]1.[H][H]>C(O)C.[C].[Pd]>[NH2:12][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][C:6]=1[N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

5

반응물 2

HCID 18953543HCID 18953543, 화합물HCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 189535484-(1H-imidazol-1-yl)pyridin-3-amine수율 91.9%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

4-(1-Imidazolyl)-3-nitropyridine (2.10 g, 11.0 mmol) was dissolved in 20 ml of ethanol. After the atmosphere was replaced with nitrogen, 0.25 g of 10% palladium-carbon was added thereto. After the atmosphere was replaced with hydrogen, hydrogen addition was conducted with stirring at room temperature for 3 days. Palladium-carbon was removed by filtration and the filtered cake was washed with ethanol. The filtrate and the washings were combined and then concentrated. The residue was purified by silica gel column chromatography [eluent: dichloromethane: methanol=8:1-6:1 (v/v)] to obtain 1.62 g of a light brown solid (yield: 91.6%).

후처리

  1. additionwas added
  2. customPalladium-carbon was removed by filtration
  3. washthe filtered cake was washed with ethanol
  4. concentrationconcentrated
  5. customThe residue was purified by silica gel column chromatography [eluent: dichloromethane: methanol=8:1-6:1 (v/v)]

출처 및 근거

ORD 기록
ord-5bff29b70bfc47e88a7c6f72accdcd38
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05262415

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