HCID 18953550, 화합물 → 4-(1-Pyrrolidinyl)-3-pyridinamine

HRID 257421노트

반응식

HRID 257421 반응식
[N:1]1([C:6]2[CH:11]=[CH:10][N:9]=[CH:8][C:7]=2[N+:12]([O-])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>O1CCOCC1.[C].[Pd]>[NH2:12][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][C:6]=1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

5

반응물 2

HCID 18953550HCID 18953550, 화합물HCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 189535394-(1-Pyrrolidinyl)-3-pyridinamine수율 90.7%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 312751,4-Dioxane용매

실험 절차

4-pyrrolidine-1-yl-3-nitropyridine (2.10 g, 10.9 mmol) was dissolved in 40 ml of 1,4-dioxane. After the atmosphere was replaced with nitrogen, 0.42 g of 10% palladium-carbon was added thereto. After the atmosphere was replaced with hydrogen, hydrogen addition was conducted with stirring at room temperature for about 15 hours. Palladium-carbon was removed by filtraton and the filtered cake was washed with 1,4-dioxane. The filtrate and the washings were combined and then concentrated to obtain 1.61 of a brown liquid (yield: 90.7%).

후처리

  1. additionwas added
  2. customPalladium-carbon was removed by filtraton
  3. washthe filtered cake was washed with 1,4-dioxane
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-210f107a0d37499d90b8db6c045be15b
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05262415

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