N-methyl-5-nitropyridin-2-amine → N2-Methylpyridine-2,5-diamine
반응식
[N+:1]([C:4]1[CH:5]=[N:6][C:7]([NH:10][CH3:11])=[CH:8][CH:9]=1)([O-])=O.[H][H]>[Pt]=O.C(O)C>[NH2:1][C:4]1[CH:5]=[N:6][C:7]([NH:10][CH3:11])=[CH:8][CH:9]=1참가 물질
5
실험 절차
To 40 ml of an ethanol solution of the methylamino compound (4 g) obtained in (a) described above was added, 400 mg of platinum oxide, followed by reaction in an atmosphere of hydrogen at room temperature for 15 hours. The solvent was thereafter removed by distallation, and the residue was purified by silica gel column chromatography (eluent: chloroform, and subsequently chloroform: methanol=20:1 (v/v)) to obtain 320 mg of the intended product as brown crystals.
후처리
- additionabove was added
- customThe solvent was thereafter removed by distallation
- customthe residue was purified by silica gel column chromatography (eluent
출처 및 근거
- ORD 기록
- ord-7b2642a21e054599908b826ac8ef3952
- 출처 데이터셋
- uspto-grants-1993_11
- 특허 번호
- US05262415
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